Flea Bytes: Duration of Antibiotics for Intra-abdominal Abscess

STOP-IT trial: In patients with intraabdominal infections WITH source control, outcomes were similar between fixed duration (4 days) vs. duration guided by clinical improvement – 2 days after the resolution of fever, leukocytosis, and ileus (mean 8 days). Both intention to treat and per-protocol analysis found no difference. However, the study was terminated early due to funding, and only enrolled half the intended patients.

Stopit

 

Reference:
N Engl J Med 2015;372:1996-2005

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