Tidings from the Citadel: Vancomycin Taper versus Fecal Transplant for Recurrent C Diff

Oral Vancomycin Followed by Fecal Transplantation Versus Tapering Oral Vancomycin Treatment for Recurrent Clostridium difficile Infection: An Open-Label, Randomized Controlled Trial – Susy S. Hota  Valerie Sales  George Tomlinson  Mary Jane Salpeter  Allison McGeer  Bryan Coburn David S. Guttman  Donald E. Low  Susan M. Poutanen  Clin Infect Dis 2017 Feb 1; 64:272

Small trial of 30 patients assess 14 days of PO vanc followed by a FMT by enema versus 6-week taper of PO vanc. Primary endpoint was c diff recurrence within 120 days. 56.2% in the fecal transplant and 41.7% in the vanc taper arms had recurrence. 5 patients in the fecal transplant arm had recurrence within 7 days.
No significant difference and the trial was stopped early. Similar rates of adverse events.
#recurrent #cdiff #clostridium #difficile #Vanc #taper #fecal #transplant