Oral Vancomycin Followed by Fecal Transplantation Versus Tapering Oral Vancomycin Treatment for Recurrent Clostridium difficile Infection: An Open-Label, Randomized Controlled Trial – Susy S. Hota Valerie Sales George Tomlinson Mary Jane Salpeter Allison McGeer Bryan Coburn David S. Guttman Donald E. Low Susan M. Poutanen Clin Infect Dis 2017 Feb 1; 64:272
Small trial of 30 patients assess 14 days of PO vanc followed by a FMT by enema versus 6-week taper of PO vanc. Primary endpoint was c diff recurrence within 120 days. 56.2% in the fecal transplant and 41.7% in the vanc taper arms had recurrence. 5 patients in the fecal transplant arm had recurrence within 7 days.
No significant difference and the trial was stopped early. Similar rates of adverse events.
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